Table 2.
Representative circular RNAs targeting angiogenesis
| CircRNA | Expression | Targeted miRNA | Downstream target | Cancer type | Functions | Clinical correlation | Reference |
|---|---|---|---|---|---|---|---|
| circPIP5K1A | Up-Regulated | MiR-600 | HIF-1α | Non-Small Cell Lung Cancer | Promoting angiogenesis by regulating VEGFR | / | [108] |
| circSCAF11 | Up-Regulated | MiR-421 | VEGFA | Glioma | Promoting angiogenesis by regulating VEGFR | Overall survival | [115] |
| Circ0001429 | Up-Regulated | MiR-205-5P | VEGFA | Bladder Cancer | Promoting angiogenesis by regulating VEGFR | Overall survival | [116] |
| circular RNA MYLK | Up-Regulated | MiR-29A | VEGFA | Bladder Cancer | Promoting angiogenesis by regulating VEGFR | TNM stage, pathological grade | [114] |
| circ_002136 | Up-Regulated | MiR-138-5P | SOX13 | Glioma | Promoting angiogenesis by regulating SOX13 | / | [118] |
| circ-SHKBP1 | Up-Regulated | MiR-544A/Mir-379 | FOXP1/FOXP2 | Glioma | Promoting angiogenesis ability of endothelial cell by regulating FOXP1/FOXP2 | / | [119] |
| circ-IARS | Up-Regulated | MiR-122 | RhoA | Pancreatic Cancer | Increasing endothelial monolayer permeability to promote cancer development | Vascular invasion, TNM stage, liver metastasis, postoperative survival time | [120] |