Fig. 3.

Immunohistochemical comparison of PFKFB4 expression between prostate cancer and BPH (magnification, 200X). a Staining for PFKFB4 in benign prostate tissue was negative. The positive staining for PFKFB4 appeared brown in prostate cancer samples, and the intensities were (b), weak; c, moderate; and (d), strong. Positive staining for the PFKFB4 protein was mainly found in the cytoplasm of PCa cells, and most intra- or extratumoral stromal cells were negative for PFKFB4