Table 3.
Prescription of daily fluid balance target during CRRT and outcomes
| Proportion of days when a daily FB target was set | |||||
|---|---|---|---|---|---|
| 0% | > 0 to < 50% | 50 to < 80% | 80 to < 100% | 100% | |
| n (%) | 13 (2%) | 27 (3%) | 201 (25%) | 266 (32%) | 313 (38%) |
| Age, median [IQR] | 58 [51–74] | 65 [55–74] | 66 [52–74] | 63 [50–73] | 67 [53–76] |
| SOFA score at CRRT initiation, mean (SD) | 14.3 (5.1) | 11.9 (4.7) | 10.1 (4.0) | 10.8 (3.5) | 9.8 (3.6) |
| Maximum SOFA score during CRRT, mean (SD) | 16.3 (4.5) | 14.7 (4.4) | 12.4 (4.0) | 13.9 (3.0) | 11.7 (3.7) |
| No FB nadir during CRRT, n (%) | 12 (92%) | 23 (81%) | 74 (37%) | 44 (17%) | 70 (22%) |
| One or more fluid boluses received during CRRT, n (%) | 11 (85%) | 21 (78%) | 151 (75%) | 238 (89%) | 202 (65%) |
| Blood transfusion received during CRRT, n (%) | 10 (77%) | 21 (78%) | 134 (67%) | 243 (91%) | 214 (68%) |
| Any diuretics received during CRRT, n (%) | 4 (31%) | 9 (33%) | 93 (46%) | 152 (57%) | 178 (57%) |
| Any noradrenaline received during RRT, n (%) | 8 (62%) | 19 (70%) | 141 (70%) | 231 (87%) | 210 (37%) |
| Percentage of days when noradrenaline was given during CRRT, median [IQR] | 100 [0–100] | 100 [0–100] | 50 [0–100] | 42 [20–80] | 42 [0–80] |
| Daily noradrenaline dose [μg], mean* | |||||
| 0 | 5 (39%) | 8 (30%) | 60 (30%) | 35 (13%) | 103 (33%) |
| 1–4999 | 0 | 5 (19%) | 18 (9%) | 42 (16%) | 37 (12%) |
| 5000–9999 | 0 | 0 | 26 (13%) | 33 (12%) | 31 (10%) |
| 10,000–49,999 | 2 (15%) | 5 (19%) | 71 (35%) | 139 (52%) | 105 (34%) |
| ≥ 50,000 | 6 (46%) | 9 (33%) | 26 (13%) | 17 (6%) | 37 (12%) |
| Days on CRRT, median [IQR] | 2 [2–3] | 3 [3–6] | 4 [3–8] | 14 [8–24] | 5 [4–9] |
| ICU mortality, n (%) | 12 (92%) | 20 (74%) | 74 (32%) | 85 (32%) | 73 (23%) |
Abbreviations: CRRT continuous renal replacement therapy, FB fluid balance, ICU intensive care unit, IQR interquartile range, SOFA Sequential Organ Failure Assessment, SD standard deviation
*Mean daily dose across all days on RRT in mg