Table 5.
Risk factors for not reaching a fluid balance nadir during CRRT
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| FB nadir reached during CRRT (n = 598) | FB nadir not reached during CRRT (n = 222) | p value | OR 95% CI | p value | |
| Cumulative FB at CRRT initiation | 1.7 [0.3–4.6] | 2.0 [0.7–4.5] | 0.055 | 0.491 | |
| SOFA score at CRRT initiation | 9.8 (3.6) | 11.9 (4.1) | < 0.001 | 1.17 (1.12–1.23) | < 0.001 |
| Days on CRRT | 8 [5–16] | 5 [3–7] | < 0.001 | 0.93 (0.90–0.95) | < 0.001 |
| Proportion of days on which a FB target was set | 0.92 [0.80–1.00] | 0.80 [0.60–1.00] | < 0.001 | 0.77 (0.70–0.84) | < 0.001 |
| Administration of one or more fluid boluses during RRT | 428 (72%) | 195 (88%) | < 0.001 | 0.754 | |
| Administration of blood transfusion during RRT | 451 (75%) | 171 (77%) | 0.632 | 0.123 | |
| Administration of one or more doses of diuretics during RRT | 331 (55%) | 105 (47%) | 0.040 | 0.750 | |
| Daily noradrenaline dose [μg], mean* | |||||
| 0 | 145 (24%) | 66 (30%) | < 0.001 | 1 | < 0.001 |
| 1–4999 | 166 (28%) | 27 (12%) | 0.47 (0.27–0.81) | ||
| 5000–9999 | 76 (13%) | 11 (5%) | 0.46 (0.22–0.97) | ||
| 10,000–49,999 | 189 (32%) | 78 (35%) | 1.07 (0.68–1.68) | ||
| ≥ 50,000 | 22 (4%) | 40 (18%) | 2.59 (1.31–5.14) | ||
Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, FB fluid balance, ICU intensive care unit, OR odds ratio, SOFA sequential organ failure assessment
Values expressed as n (%), mean (standard deviation) or median [interquartile range]. C-statistic 0.76, Hosmer Lemeshow goodness of fit: p = 0.21
*Mean daily dose across all days on RRT