Table 6.

Multivariable analysis

	ICU mortality			Hospital mortality
	OR	95% CI	p value	OR	95% CI	p value
Age	1.02	1.01–1.03	< 0.001	1.02	1.01–1.03	0.001
Male sex	1.21	0.84–1.73	0.30	1.23	0.89–1.70	0.23
BMI
< 20	2.43	1.01–5.82		3.09	1.32–7.23
20 to < 25	1		0.22	1		0.037
25 to < 30	0.90	0.59–1.39		0.95	0.64–1.43
30 to < 40	0.84	0.53–1.31		0.86	0.57–1.31
40 or higher	0.86	0.42–1.78		1.53	0.79–2.97
SOFA score on the 1st day of CRRT	1.17	1.11–1.23	< 0.001	1.13	1.08–1.16	< 0.001
Highest arterial lactate concentration on 1st day of CRRT (μmol/l)	1.03	0.98–1.07	0.23	1.04	1.00–1.08	0.065
Hb on 1st day of CRRT (per 10 g/dl)	0.99	0.90–1.09	0.86	0.98	0.89–1.07	0.61
Daily noradrenaline dose [μg], mean*
0	1		< 0.001	1		0.002
1–4999	0.87	0.50–1.51		0.92	0.56–1.51
5000–9999	0.96	0.48–1.93		1.12	0.62–2.03
10,000–49,999	2.60	1.62–4.17		1.94	1.25–3.00
≥ 50,000	2.77	1.40–5.50		2.10	1.06–4.19
Cumulative FB at CRRT initiation (per 1000 ml)	1.01	0.97–1.05	0.80	1.01	0.97–1.05	0.59
Delta cumulative FB
No nadir reached	1		0.048	1		0.010
< 2500 ml reduction	0.84	0.48–1.46		0.77	0.54–1.29
2500–4999 ml reduction	0.57	0.36–0.91		0.67	0.43–1.03
≥ 5000 ml reduction	0.57	0.33–0.99		0.43	0.26–0.71

Abbreviations: BW body weight, BMI body mass index, CI confidence interval, CRRT continuous renal replacement therapy, FB fluid balance, Hb haemoglobin in [g/dl], ICU intensive care unit, IQR interquartile range, OR odds ratio, SOFA Sequential Organ Failure Assessment

*Mean daily dose across all days on RRT

There were no significant interactions between cumulative and delta fluid balance (ICU model: p = 0.87, hospital model: p = 0.66). C-statistic: ICU model c = 0.77, hospital model c = 0.73, Hosmer Lemeshow goodness of fit: ICU model: p = 0.31, hospital model: p = 0.33