Table 1.

Study eligibility criteria

Inclusion criteria

Aged between 18 and 80 years

Reflux in the great saphenous vein of > 0.5 s

Diameter of the saphenous vein between 2 and 20 mm (standing position)

One or more of the symptoms related to the incompetent saphenous vein

CEAP classification of C2 through C5

Exclusion criteria

Previous treatment in the targeted vein segment

Tortuous vein in which the delivery catheter cannot be inserted

Aneurysm of target-vein segment of > 20 mm

Daily use of narcotic or pain medications to control pain associated with reflux

Known hypercoagulable disorder

Active malignancy

Regular or current use of systemic anticoagulation

Previous deep vein thrombosis/pulmonary embolism or active acute superficial thrombophlebitis

Unable to comply with the schedule and protocol evaluations

Unable to ambulate

Unable to provide informed consent

Currently pregnant or breastfeeding

Known sensitivity to cyanoacrylate adhesives

Participation in another clinical study that did not reach the primary endpoint within 30 days prior to enrollment

CEAP Clinical, Etiologic, Anatomic, and Pathophysiologic