Table 2.
Differential methylation regions corresponding genes and β values of diabetic retinopathy and nondiabetic retinopathy subjects in the discovery study
| DMR | Gene | β value | P value | ||
|---|---|---|---|---|---|
| DR group | Non-DR group | Difference | |||
| TSS1500 | MDFI | 0.414024 | 0.554308 | − 0.140284 | 0.000962 |
| PGBD5 | 0.538043 | 0.365315 | 0.17273 | 0.000358 | |
| TSS200 | ADRA2C | 0.042839 | 0.27238 | − 0.229541 | 0.002349 |
| UTR5 | CNTNAP5 | 0.256273 | 0.445609 | − 0.189336 | 0.012985 |
| EXON1 | PRSS23 | 0.027501 | 0.168661 | − 0.14116 | 0.018082 |
| S100A13 | 0.509213 | 0.660521 | − 0.151308 | 1.1E−05 | |
| TIGD5 | 0.112166 | 0.27952 | − 0.167354 | 0.001071 | |
| GENE BODY | COQ3 | 0.463529 | 0.637303 | − 0.173774 | 0.021585 |
| MOSC2 | 0.451381 | 0.634923 | − 0.183542 | 0.00509 | |
| UTR3 | FLVCR1 | 0.442131 | 0.619624 | − 0.177493 | 0.048598 |
| HLA-B | 0.088913 | 0.308803 | − 0.21989 | 0.001479 | |
| RRH | 0.800984 | 0.629198 | 0.17179 | 0.003695 | |
| ISLAND | chr1:19110720-19110932 | 0.56494 | 0.708782 | − 0.143842 | 0.038852 |
| chr15:22982192-22982410 | 0.93844 | 0.771584 | 0.16686 | 0.035381 | |
| NSHELF | chr12:120933649-120934713 | 0.376657 | 0.609267 | − 0.23261 | 0.026168 |
| chr14:105603310-105603532 | 0.730847 | 0.544063 | 0.18678 | 0.03281 | |
| chr17:35165323-35165983 | 0.636466 | 0.394896 | 0.24157 | 0.009788 | |
| chr18:21083161-21084153 | 0.890993 | 0.690135 | 0.20086 | 0.008755 | |
| chr4:4119800-4120035 | 0.5605 | 0.294444 | 0.26606 | 0.017018 | |
| chr4:47427692-47427905 | 0.54905 | 0.703312 | − 0.154262 | 0.04677 | |
| chr4:81951941-81952808 | 0.65228 | 0.810351 | − 0.158072 | 0.026402 | |
| NSHORE | chr5:178565716-178565918 | 0.721065 | 0.861094 | − 0.140029 | 0.008616 |
| SSHELF | chr1:219786334-219786562 | 0.218291 | 0.432222 | − 0.213931 | 0.00867 |
| chr13:26586287-26586761 | 0.603417 | 0.764495 | − 0.161078 | 0.039872 | |
| chr14:71108008-71109332 | 0.876179 | 0.589911 | 0.28627 | 0.00262 | |
| chr16:25268786-25269728 | 0.878063 | 0.59304 | 0.28502 | 0.001536 | |
| chr1:6761295-6762131 | 0.719637 | 0.559159 | 0.16048 | 0.011819 | |
| chr16:85305690-85305892 | 0.365183 | 0.543685 | − 0.178502 | 0.045519 | |
| chr22:20459267-20461473 | 0.495691 | 0.667066 | − 0.171375 | 0.037325 | |
| chr2:8825106-8826188 | 0.724995 | 0.875096 | − 0.1501 | 0.025348 | |
| chr4:120987617-120988156 | 0.859063 | 0.656103 | 0.20296 | 0.000565 | |
| SSHORE | chr10:54631211-54631426 | 0.480326 | 0.686335 | − 0.206009 | 0.006475 |
| chr1:19110720-19110932 | 0.547506 | 0.705954 | − 0.158447 | 0.002265 | |
| chr6:169195967-169196186 | 0.577833 | 0.762515 | − 0.184682 | 0.010715 | |
DMR differentially methylated region, DR diabetic retinopathy, TSS transcriptional start site, UTR untranslated region, MDFI MyoD family inhibitor, PGBD5 piggyBac transposable element derived 5, ADRA2Cadrenoceptor alpha 2C, CNTNAP5 contactin-associated protein-like 5, PRSS23serine protease 23, S100A13calcium-binding protein A13, TIGD5tigger transposable element derived 5, COQ3coenzyme Q3 methyltransferase, MOSC2mitochondrial amidoxime-reducing component 2, FLVCR1feline leukemia virus sub-group C cellular receptor 1, HLA-Bmajor histocompatibility complex, class I B, RRH retinal pigment epithelium-derived rhodopsin homolog