Table 3.
Genes harboring differential methylation sites (DMSs) with the top 5 differences in β values between diabetic retinopathy (DR) and non-DR subjects in the discovery study
| DMS | Gene | C | Location | β value | P value | ||
|---|---|---|---|---|---|---|---|
| DR group | Non-DR group | Difference | |||||
| cg11596404 | S100A13 | 1 | TSS200; 5′ UTR; TSS1500; | 0.530201 | 0.679582 | − 0.149381 | 6.39E−07 |
| cg02873163 | S100A13 | 1 | TSS200; 5′ UTR; 5′ UTR; TSS1500 | 0.550267 | 0.706868 | − 0.156601 | 6.42E−06 |
| cg17776284 | S100A13 | 1 | 5′ UTR; TSS200; 1stExon; TSS1500 | 0.475831 | 0.621 | − 0.145169 | 1.51E−05 |
| cg11915664 | S100A13 | 1 | TSS200; 5′ UTR; TSS1500 | 0.410099 | 0.552284 | − 0.142185 | 1.55E−05 |
| cg11343894 | S100A13 | 1 | 5′ UTR; 1stExon; TSS200;TSS150; | 0.504602 | 0.658721 | − 0.154119 | 1.78E−05 |
DMS differentially methylated site, DR diabetic retinopathy, C chromosome, S100A13calcium-binding protein A13, TSS transcriptional start site, UTR untranslated region