Table 4.
Association between decision-making factors and the strength of recommendations
| Mixed-effect model [logistic regression] | Dependent variable: weak against; strong against odds ratio (OR) with 95% confidence interval (CI) |
|---|---|
| Fixed effect | |
| Role: chair (reference category) | |
| methodologist | 11.7 (95% CI 1.50–91.4; P = .019) |
| Patient representative | 1.28 (95% CI .070–23.4; P = .87) |
| Panel member | 2.34 (95% CI .558–9.83; P = .25) |
| Vulnerable population | |
| Yes vs. no | 3.97 (95% CI 1.30–12.1; P = .015) |
| Pressured to “vote” certain way | 0.34 (95% CI .036–3.28; P = .35) |
| Recused from “voting” | |
| Yes vs. no | 3.34 (95% CI 1.29–8.65;P = .013)a |
| Age (per decade) | 4.8 (95% CI 1.8–12.76; P = .002) |
| Sex | |
| Female vs. male | 0.56 (95% CI .247–1.43; P = .25) |
| Experience (years in management of given condition) | 0.87 (95% CI .79–.96;P = .007) |
| Expertise (consider oneself with higher, same or low expertise than most other experts) | 0.46 (95% CI .18–1.15; P = .09) |
| Exposure (# of patients per month with given condition) | 0.84 (95% CI .58–1.20; P = .33) |
| Objectivism (tendency to seek empirical information) | 1.15 (95% CI .28–4.63; P = .84) |
| Tendency toward rational (analytical) thinking | 0.215 (95% CI .063–.729; P = .014) |
| Tendency toward experiential–intuitive thinking | 1.32 (95% CI .60–2.90; P = .49) |
| Satisficing (tendency to accept “good” enough solution | 1.31 (95% CI .36–4.72; P = .68) |
| Maximizing(decision difficulty)–degree difficulty experienced when making choices among abundant options | 1.45 (95% CI .74–2.85; P = .28) |
| Maximizing(alternative search)-tendency to expand resources in search for best possible solution | 1.00 (95% CI .55–1.84; P = .99) |
| Intolerance of uncertainty | 0.16 (95% CI .05–.49; P = .001) |
| Regret of making a wrong recommendation | OR = 1.01 (95% CI .97–1.06; P = .62) |
| Certainty in Evidence | OR = 0.98 (95% CI .57–1.68; P = .94) |
| Importance of patients’ values and preferences | 2.26 (95% CI 1.32–3.87; P = .003) |
| Balance between benefits and harms | 0.78 (95% CI .52–1.23; P = .31) |
| Importance of cost and resources | 1.01 (95% CI .60–1.69; P = .97) |
| Random intercepts | |
| Panel (variance) | 1.54 (95% CI .380–6.23) |
| Participant within panel (variance) | 1.47 × 10−36 |
Bolded text refers to statistically significant findings.
a
when interactions with the certainty of evidence was taken into account, OR = 4.63 (95% CI 0.814 to 26.38; P = 0.084).