Table 1.
Expression changes of target antigens of selected MAbs in hMSCs stimulated with osteogenic inducers and in Runx2 knockdown U2OS cells
| Clone | Isotype | hMSCs | Runx2 knockdown U2OS | |
|---|---|---|---|---|
| TGF-β1 + BMP-2 | ODM | |||
| CD146 | – | ↑ | ↑ | ─ |
| ER3-A7 | IgG1, κ | ↑↑ | ↑↑ | ─ |
| ER3-F3 | IgG2a, κ | ↑ | ↑↑ | ↓ |
| ER7-A7 | IgG2a, κ | ↑ | ↑↑ | ↓ |
| ER7-A8 | IgG1, κ | ↑ | ↑↑↑ | ↓↓ |
| MR1-B1 | IgG2a, κ | ↑↑ | ↑↑↑ | ↓↓ |
| MR1-G2 | IgG1, κ | ↑ | ↓↓ | ↑ |
| MR14-E5 | IgG2a, κ | ↑ | ↓↓ | ↑ |
| MR14-F5 | IgG2a, κ | ↑ | ↓ | ↑ |
| MR16-E3 | IgG2a, κ | ↑ | ↑↑↑ | ─ |
↑ weak upregulation; ↑↑ medium upregulation; ↑↑↑, strong upregulation; ↓ weak downregulation; ↓↓ medium downregulation; ─ no change