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Roflumilast alleviated sepsis-induced kidney dysfunction. The serum levels of creatinine (Cre) (A), blood urea nitrogen (BUN) (B), urine levels of kidney injury molecule-1 (KIM-1) (C), and neutrophil gelatinase-associated lipocalin (NGAL) (D) were detected using commercially available assay kits. *** P<0.001 versus Sham; ## P<0.01, ### P<0.001, versus CLP. ROF – roflumilast; CLP – cecal ligation and puncture surgery.
