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Anti-EGFR p580 antibodies bind homologous HER2 and HER3 peptides and proteins. Sera from Balb/c mice immunized with Asp p580 or iso-Asp p580 were tested by ELISA for antibody binding. a Immune sera binding to HER2 p585 peptide. b Immune sera binding to HER3 p574 peptide. c Immune sera binding to recombinant HER2 extracellular domain. d Immune sera binding to recombinant HER3 extracellular domain. Results represent nine-to-ten mice per group. *p < 0.05; **p < 0.01; ***p < 0.001
