Table 1.
Sources of stem cells and their roles in the treatment of kidney diseases.
Sources of stem cells | Disease model | Mechanisms | References |
---|---|---|---|
BMSCs | Acute kidney injury | Transdifferentiation | Wong et al.;8 |
hUCMSC-exosome, ADSCs-exosome, BMSCs-exosome, hAD-MSCs-exosome, UC-MSCs-exosome. | Cisplatin-induced Nephrotoxicity; Diabetic nephropathy; Acute kidney injury; AKI-CKD transmission; High phosphorus-induced vascular smooth muscle cells calcification; Unilateral ureteral obstruction. |
paracrine | Guo et al.;28 Zhang et al.;29 Zhu et al.;30 Wang et al.;33 Jia et al.;35 Jin ;36 Kilpinen et al.;80 Zhong et al.;106 Nagaishi et al.107 |
hUC-MSCs, BMSCs, hUCMSC-exosomes, ASCs, ADSCs-exosome. | Acute kidney injury; Cr (VI)-injured kidney; Diabetic nephropathy; Cisplatin-induced AKI. |
Autophagy | Ebrahim et al.;24 Wang et al.;33 Jin et al.;36 Yin et al.;38 Rashed et al.;39 Xiang et al.;40 Tang et al.41 |
BMSCs, PSC-derived endothelial progenitor cells, uADSCs, hUCMSCs, USCs. | Chromium-injured kidney; Acute kidney injury; Cisplatin-induced acute kidney injury; Rhabdomyolysis-induced acute kidney injury model; Adriamycin nephropathy; Diabetic nephropathy; Unilateral ureteral obstruction; Obesity-associated kidney injury; Renal artery stenosis; Chronic kidney disease. |
Anti-apotosis | Jin et al.;36 Yin et al.;38 Rashed et al.;39 Li et al.;48 Song et al.;54 Liu et al.;55 Xie et al.;56 Shen et al.;59 Zhang et al.;60 Zhang et al.;61 Jiao et al.;62 Tian et al.;63 Geng et al.;64 Zhu et al.79 |
hU-MSCs, iPS-MSCs, BMSCs, hAFS, USCs, ADSCs. | Lupus nephritis; Obesity-associated kidney injury; Cardiorenal syndrome type II; Acute kidney injury. |
Anti-inflammation | Li et al.;48 Zhang et al.;60 Tian et al.;63 Vescovo et al.;67 Liu et al.68 |
MSCs, ADSCs | Acute kidney injury; Unilateral ureteral obstruction; Chronic kidney disease; Diabetic nephropathy; Systemic lupus erythematosus. |
Immunoregulation | Shi et al.;73 Vasandan et al.;74 Wang et al.;75 Mittal et al.;76 Xing et al.;77 Rota et al.;78 Li et al.;79 Hamza et al.;80 He et al.81 |