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. 2020 May 29;13:4905–4915. doi: 10.2147/OTT.S245531

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© 2020 Liu et al.

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Silencing TCF4 sensitizes A375 and SK-Mel-28 cells to Vemurafenib. (A) Western blot was performed to examine the expression of TCF4 in Vemurafenib-resistant A375 and SK-Mel-28 cells after siRNA transfection (left), and quantification of the bands (right). (B) CCK-8 assay was performed to measure the cell viability in A375/Vem and SK-Mel-28/Vem cells after siRNA transfection and Vemurafenib treatment. (C) CCK-8 assay was performed to measure the cell viability at different times after siRNA transfection and vemurafenib treatment (A375/Vem, 3 μM; SK-Mel-28/Vem, 6 μM). Each experiment was performed three times. Vem, vemurafenib. *p<0.05.