Table 2.

The inclusion of chloroquine phosphate on the guidelines

	Guideline name	Publishing organization	Key information
2020.02.19	Novel coronavirus pneumonia diagnosis and treatment plan (provisional 6th ed)[24]	National Health Commission	Eligibility: general treatments for all COVID-19 cases, regardless of disease severity Dosage: 500 mg, twice per day, use no longer than 10 days
2020.02.20	Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia[25]	Health Commission of Guangdong Province for chloroquine in the COVID-19 treatment	It recommended chloroquine phosphate tablet, 500 mg twice per day for 10 days for patients diagnosed as mild, moderate, and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine. Contraindicated to use combined with macrolide antibiotics, including azithromycin.
2020.02.21	Close monitoring the adverse effects of chloroquine phosphate for the treatment of novel coronavirus pneumonia[26]	Health Commission of Hubei Province	Chloroquine phosphate can cause acute death. Lethal dose for adults is 2–4 g.
2020.02.28	Notifications on the adjustment of dosage of chloroquine phosphate for the treatment of novel coronavirus pneumonia[27]	National Health Commission	Chloroquine phosphate (500 mg bid for 7 days for adults aged 18–65 years with body weight over 50 kg; 500 mg bid for days 1 and 2, and 500 mg qd for days 3–7 for adults with body weight below 50 kg) Contraindicated to use combined with macrolide antibiotics, including azithromycin.
2020.03.02	Shanghai expert consensus on the integrated treatment for novel coronavirus pneumonia[28]	Shanghai Expert Panel on the Clinical Treatments for COVID-19	Hydroxychloroquine sulphate and chloroquine phosphate were both recommended.
2020. 03.03	Novel coronavirus pneumonia diagnosis and treatment plan (provisional 7th edition)[29]	National Health Commission	Chloroquine phosphate (500 mg bid for 7 days for adults aged 18–65 years with body weight over 50 kg; 500 mg bid for days 1 and 2 and 500 mg qd for days 3–7 for adults with body weight below 50 kg)
2020.03.05	Guangdong expert consensus on the Chinese integrative medicines for the prevention and treatment of COVID-19[30]	Guangdong Association of Integrative Medicine	Chloroquine phosphate (500 mg bid for 7 days for adults aged 18–65 years with body weight over 50 kg; 500 mg bid for days 1 and 2 and 500 mg qd for days 3–7 for adults with body weight below 50 kg)
2020.03.15	Shandong expert consensus on the diagnosis and treatment for novel coronavirus pneumonia[31]	Shandong Expert Panel on the Clinical Treatments for COVID-19	Hydroxychloroquine sulphate (200 mg, 3 times per day)