Table 3. Infection outcomes of mouse-adapted SARS-CoV strains.
| Strains | Urbani (wt) | Urbani+S | Urbani+N9 | Urbani+N9/S | MA15 | MA+N9/S | MA20 | v2163 | Urbani | MA15 |
|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | One-year-old BALB/c | 5∼10 week BALB/c | ||||||||
| Inoculation dose | 1 × 105 PFU | 1 × 105.5 CCID50 | ||||||||
| Peak viral load in lung at 2∼4 dpi | ∼105 PFU/g |
∼107.2 PFU/g |
∼108 PFU/g |
∼107.5 PFU/g |
∼106 PFU/g |
∼106.5 PFU/g |
∼106.5 PFU/g |
∼107.5 PFU/g |
∼105.8 CCID50/g | ∼106.6 CCID50/g |
| Mortality rate | None | 100% at 8dpi | None | 100% at 4dpi | 100% at 5dpi | 100% at 4dpi | ND | 100% at 6dpi | None | 90% at10 dpi |
| Mean day of death (days) | – | 6.0 ± 1.26 | – | 3.2 ± 0.44 | 3.8 ± 1.09 | 3.2 ± 0.40 | ND | 4.8 ± 1.8 | – | 6.8 ± 1.4 |
| LD50 | – | 10E4.4 | – | 10E2.5 | <10E2 | 10E2.3 | ND | 10E3.3 | – | – |