Table 5.

Composition of various SMEDDS formulation suggested by Design Expert^® in the study and response.

Formulation code	Excipients ratio			Y1 (nm)	Y2 (%)	Y3 (s)
	X1 (%)	X2 (%)	X3 (%)
F1	0.10	0.40	0.50	13.68	93.2	26
F2	0.16	0.25	0.59	60.94	95	41
F3	0.17	0.40	0.43	52.23	91	25
F4	0.05	0.48	0.47	11.39	90	15
F5	0.10	0.25	0.65	22.69	97	39
F6	0.05	0.38	0.57	15.89	94.5	17
F7	0.25	0.5	0.25	87.39	86	24
F8	0.18	0.30	0.52	40.79	94.9	32
F9	0.23	0.25	0.52	119.8	91.7	36
F10	0.25	0.35	0.40	111.1	91	28
F11	0.05	0.32	0.63	13.91	98.5	18
F12	0.21	0.44	0.35	105	87.7	21
F13	0.10	0.40	0.50	13.6	93	26
F14	0.14	0.5	0.36	14.45	88	20

Independent variable: X₁ as oil percentage (Capmul MCM EP), X₂ as surfactant percentage (Tween 20), and X₃ as a co-surfactant percentage (Transcutol P). Dependent variables: globule size (Y₁), %CDR (Y₂) and self-emulsification time (Y₃).