Table 1. Effects of LT on hypercholesterolemia-induced changes in serum biochemistry.
| Parameters | Control | HCD | LT(10) | LT(20) |
|---|---|---|---|---|
| TC (mg/dl) | 47.95 ± 7.42 | 112.94 ± 28.51***a | 69.84 ± 22.45***b | 60 ± 10***b |
| TG (mg/dl) | 21.03 ± 9.24 | 59.05 ± 12.24***a | 43.11 ± 6.67**b | 38.477 ± 6.79**b |
| LDL (mg/dl) | 37.79 ± 12.43 | 55.24 ± 10.59*a | 37.94 ± 13.24**b | 37.95 ± 6.2***b |
| HDL (mg/dl) | 37.8 ± 6.23 | 32.56 ± 6.85 | 33.33 ± 2.54 | 34.37 ± 2.82 |
| CK-B (U/L) | 10.26 ± 165 | 22.08 ± 3.74***a | 14.21 ± 4.45***b | 12.32 ± 2.89***b |
| CK-MB (U/L) | 20.54 ± 3.3 | 44.19 ± 11.48***a | 26.25 ± 6.99***b | 23.33 ± 8.3***b |
| ALT (U/L) | 17.65 ± 2.16***a | 36.93 ± 5.96 | 28.61 ± 5.10**b | 22.12 ± 4.90***b |
| AST (U/L) | 36.67 ± 6.94 | 54.17 ± 4.67**a | 41.24 ± 7.50**b | 37.40 ± 8.75b |
| Creatinine (mg/dl) | 2.06 ± 0.67 | 6.18 ± 2.00***a | 4.12 ± 0.92*b | 3.95 ± 1.23*b |
| Urea (mg/dl) | 19.87 ± 3.93 | 59.60 ± 11.79***a | 39.19 ± 10.10**b | 32.44 ± 10.59***b |
Data were expressed as mean ± SEM (n = 6) and analyzed using one-way ANOVA followed by Student Newman–Keuls as post hoc test. aControl vs. HCD group; bHCD vs. LT(10) or LT(20). P values consider significant when *P < 0.05, **P < 0.01 and ***P < 0.001. Abbreviations: Total cholesterol (TC); triglycerides (TG); low-density lipoprotein-cholesterol (LDL); high-density lipoprotein-cholesterol (HDL); creatine kinase-B (CK-B); creatine kinase-MB (CK-MB); alanine aminotransferase (ALT); aspartate aminotransferase (AST).