. 2020 May 13;9(1):928–939. doi: 10.1080/22221751.2020.1757998

Table 2. Association between HBsAg C-terminus mutations correlated with HBsAg <1000 IU/mL and other HBsAg C-terminus mutations.

Mutations associated with HBsAg<1000 IU/ml	Correlated mutations	Phi^a	P-Value^a	N (%) of the pairs of HBsAg mutations
Mutations associated with HBsAg<1000 IU/ml	Correlated mutations	Phi^a	P-Value^a	<1000 IU/ml^b	>1000 IU/ml^b
V190A	F220L	0.30	0.003	5 (6.5)	0
Y206F	V194A	0.23	0.009	4 (5.2)	1 (0.7)
	M197T	0.32	0.002	4 (5.2)	0
	S204T	0.26	0.006	4 (5.2)	0
	S210R	0.33	<0.001	7 (9.1)	1 (0.7)
S204N	L205P	0.25	0.004	4 (5.2)	1 (0.7)
S210N	F220L	0.30	0.003	4 (5.2)	0

^aBinomial correlation coefficient (Phi) was calculated to assess the strength of association for each pair of identified mutations. Statistically significant differences were assessed by Fisher Exact Test.

^bThe prevalence of the pairs of mutations was calculated in the group of 77 patients with HBsAg <1,000IU/ml and 151 patients with HBsAg >1,000IU/ml. All the differences in the prevalence were statistically significant (P<0.05) by Fisher exact test.