Table 3. Factors associated with HBsAg levels <1000 IU/ml in HBeAg-negative patients infected with HBV genotype D.

Variables	Univariate analysisa		Multivariate analysisa
	Crude OR [95% CI]	p-value	Adjusted OR [95% CI]	p-value
Gender (Female vs. Maleb)	1.21 (0.69-2.14)	0.49
Age (for 1 year increase)	1.04 (1.02-1.06)	<0.001	1.04 (1.02-1.07)	0.002
HBV-DNA, log10 IU/ml	0.41 (0.30-0.56)	<0.001	0.46 (0.33-0.63)	<0.001
ALT, U/L	1.00 (0.99-1.00)	0.143
≥1 pair of mutations	39.34 (5.11-303.22)	<0.001	14.75 (1.83-118.79)	0.011

^aUnivariate and multivariate logistic regression analysis was performed on 228 HBeAg-negative patients infected with HBV genotype D. The following variables were considered: gender, age, HBV-DNA log10, ALT, >1 pair of mutations associated with HBsAg<1000 IU/ml. Variables with P-value<0.05 in univariate analysis were included in multivariate analysis.

^bReference group