Table 1.
Demographic and clinical characteristics of patients with lupus nephritis and ANCA glomerulonephritis.
| Parameters | Total n = 872 |
Lupus nephritis n = 806 |
ANCA glomerulonephritis n = 66 |
p Value |
|---|---|---|---|---|
| Age (years) | 34.2 ± 12.6 | 32.9 ± 11.4 | 49.6 ± 16.1 | <.001 |
| Male, n (%) | 151 (17.3) | 119 (14.8) | 32 (48.5) | <.001 |
| With at least one episode of IRH, n (%) | 304 (34.9) | 269 (33.4) | 35 (53.0) | .001 |
| Previous history, n (%) | ||||
| With diabetes | 20 (2.3) | 13 (1.6) | 7 (10.6) | <.001 |
| With hepatitis | 11 (1.3) | 10 (1.2) | 1 (1.5) | .852 |
| With cytomegalovirus infection | 6 (0.7) | 4 (0.5) | 2 (3.0) | .067 |
| With tuberculosis history | 15 (1.7) | 9 (1.1) | 6 (9.1) | <.001 |
| Leukocyte (×109/L) | 7.5 ± 4.0 | 7.3 ± 4.1 | 9.0 ± 2.8 | .001 |
| Neutrophil (×109/L) | 5.6 ± 3.5 | 5.4 ± 3.6 | 7.0 ± 2.5 | <.001 |
| Lymphocyte (×109/L) | 1.4 ± 1.0 | 1.4 ± 1.1 | 1.3 ± 0.6 | .554 |
| Monocyte (×109/L) | 0.4 ± 0.3 | 0.4 ± 0.3 | 0.5 ± 0.4 | .188 |
| Hemoglobin (g/L) | 98.6 ± 23.0 | 98.8 ± 23.4 | 95.9 ± 16.6 | .321 |
| Albumin (g/L) | 26.5 ± 6.6 | 25.9 ± 6.5 | 33.3 ± 3.9 | <.001 |
| Globulin (g/L) | 25.7 ± 8.1 | 25.7 ± 8.3 | 25.9 ± 5.6 | .836 |
| Serum creatinine (μmol/L) | 70.3 (52.3, 136.5) | 68.0 (51.2, 119.9) | 288.5 (150.0, 382.3) | <.001 |
| eGFR (mL/min/1.73 m2) | 93.7 (49.9, 118.6) | 97.0 (59.9, 120.1) | 18.1 (11.7, 41.1) | <.001 |
| Uric acid (μmol/L) | 392.9 ± 148.0 | 391.9 ± 151.1 | 404.7 ± 102.8 | .500 |
| Initial dose of prednisone (mg/d) | 51.0 ± 12.9 | 51.5 ± 12.6 | 44.9 ± 15.4 | <.001 |
| Immunosuppressive agents, n (%) | .378 | |||
| CTX | 733 (84.1) | 675 (83.8) | 58 (87.9) | |
| MMF | 139 (15.9) | 131 (16.2) | 8 (12.1) | |
IRH: infection-related hospitalization; CMV: cytomegalovirus; eGFR: estimated glomerular filtration rate; CTX: cyclophosphamide; MMF: mycophenolate mofetil.
Values were expressed as mean ± SD, median (interquartile range), or number (percentage).