Table 4.
Risk factors associated with IRH.
| Parameters | Univariate Cox regression |
Multivariable Cox regression |
||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age (per 1-year interval) | 1.01 (1.00, 1.02) | .016 | 1.00 (0.99, 1.01) | .990 |
| Gender (male vs. female) | 1.24 (0.93, 1.64) | .137 | ||
| Primary kidney diseases | ||||
| Lupus nephritis | 1 (reference) | 1 (reference) | ||
| ANCA glomerulonephritis | 1.65 (1.16, 2.35) | .005 | 1.62 (1.06, 2.49) | .027 |
| Previous history | ||||
| With diabetes | 2.07 (1.19, 3.61) | .010 | 1.82 (1.03, 3.22) | .039 |
| With hepatitis | 0.77 (0.25, 2.39) | .644 | ||
| With cytomegalovirus infection | 2.13 (0.79, 5.70) | .134 | ||
| With tuberculosis history | 1.42 (0.67, 3.01) | .356 | ||
| Leukocyte (per 1.0 × 109/L) | 1.01 (0.98, 1.04) | .589 | ||
| Neutrophil (per 1.0 × 109/L) | 1.02 (0.99, 1.05) | .286 | ||
| Lymphocyte (per 1.0 × 109/L) | 0.91 (0.81, 1.02) | .088 | 1.02 (0.90, 1.15) | .767 |
| Hemoglobin (per 1.0 g/L) | 1.00 (0.99, 1.00) | .167 | ||
| Albumin (per 1.0 g/L) | 0.95 (0.94, 0.98) | <.001 | 0.96 (0.94, 0.98) | <.001 |
| Globulin (per 1.0 g/L) | 0.96 (0.95, 0.98) | <.001 | 0.98 (0.96, 0.99) | .008 |
| Serum creatinine (per 1.0 μmol/L) | 1.00 (1.00, 1.00) | <.001 | ||
| eGFR (per 1.0 mL/min/1.73 m2) | 0.99 (0.99, 0.99) | <.001 | 0.99 (0.99, 1.00) | <.001 |
| Uric acid (per 1.0 μmol/L) | 1.00 (1.00, 1.00) | <.001 | ||
| Initial dose of prednisone (every 1 mg/d) | 1.01 (1.00, 1.02) | .015 | 1.01 (1.00, 1.02) | .013 |
| Immunosuppressive agents | ||||
| CTX | 1 (reference) | |||
| MMF | 0.98 (0.72, 1.33) | .890 | ||
IRH: infection-related hospitalization; eGFR: estimated glomerular filtration rate; CTX: cyclophosphamide; MMF: mycophenolate mofetil.
Variables with p < .1 in univariate analysis and clinical significance were included in multivariable analysis.