Table 5.

A summary of vesicular lipid drug delivery systems that have been invented by formulators in the past years.

Vesicular system	Definition
Liposomes	Natural or synthetic bilayer/s of phospholipids and cholesterol as a fluidity modifier (Bansal et al., 2012; Jain et al., 2014).
Niosomes	One or more bilayers consisting of amphiphilic nonionic surfactants instead of phospholipids (Bansal et al., 2012; Jain et al., 2014).
Trasferosomes	Flexible and deformable liposomes (Bansal et al., 2012; Jain et al., 2014).
Aquasomes	A solid ceramic core with a carbohydrate coat (Jain et al., 2014).
Colloidosomes	Spherical structures with a hollow core and a coat of particles that are formed by coagulation at the interface of emulsion droplets (Jain et al., 2014).
Cubosomes	Cubic shaped vesicles (Jain et al., 2014).
Sphingosomes	Liposomes formed of sphingolipids instead of phospholipids (Jain et al., 2014).
Ufasomes	Unsaturated fatty acids forming bilayered structure that attach to the surface of the skin (Patel et al., 2011).
Cryptosmes	Vesicular structures with a coat of phosphatidyl choline and phosphatidyl ethanolamine (U. et al., 2019).
Discomes	Disc-shaped structures similar to niosomes (Uchegbu et al., 1992).
Emulsomes	Drug nano-carriers with a solid lipid core and a phospholipid bilayer surface (Zhou and Chen, 2015).
Enzymosomes	Liposomes with a functional group of one or more enzyme (S. et al., 2017).
Genosomes	Vesicles that consists of genetic material and positively charged lipids (Tadwee et al., 2011).
Ethosomes	Liposomes that contain: ethanol, water and a penetration enhancer (Tadwee et al., 2011).
Photosomes	A liposome that incorporates photolysase enzyme (Tadwee et al., 2011).
Virosomes	Phospholipid vesicles with virus-extracted proteins (Tadwee et al., 2011).
Vesosomes	Multivesicular structures synthesized using ethanol and certain types of phospholipids (Tadwee et al., 2011).
Proteasomes	Lipid vesicles with protease enzymes (Tanaka, 2009).
Herbosomes	Liposome-like structures incorporating phytochemicals (Anwana, 2015).
Layerosomes	Phospholipid bilayer vesicles with a surface of polyelectrolytes (Agnihotri et al., 2004).
Pharmacosomes	Very fine particles consisting of covalently linked drug and lipids (Bansal et al., 2012).