Table 1:
Top 15 angiogenesis stimulator genes expressed in MSC CM treated HOVEC.
| Gene | Expression change | Function |
|---|---|---|
| PROK2 | 0.722876059 | Ovarian angiogenesis via MAPK and PI3K/AKT pathway [34,35]. |
| TGFA | 0.62270244 | angiogenesis in carcinoma via PI3K [36,37] |
| CCL11 | 0.467909147 | angiogenesis via PI3K/AKT [38] |
| LEP | 0.412112411 | angiogenesis via JAK2/STAT3 and PI3K/AKT [43] |
| EGF | 0.40089547 | angiogenesis via PI3K/AKT [44,45] |
| CXCL9 | 0.35104549 | angiogenesis via MAPK/APK [46] |
| TNF | 0.333847649 | angiogenesis via NF-KB [47,48] |
| TYMP | 0.301952601 | oxidation stress, increase VEGF [49] |
| VEGFA | 0.272543655 | Stimulate Angiogenesis |
| SPHK1 | 0.179885402 | Activate S1P and AKT pathway [50] |
| PLG | 0.16577538 | Plasminogen, support VEGF, bFGF induced angiogenesis [51] |
| ERBB2 | 0.159172594 | Stimulate VEGF expression [52] |
| MMP9 | 0.158525877 | Key angiogenesis protein. Stimulated by PI3K/AKT pathway [53,54] |
| LECT1 | 0.153201634 | Leukocyte Cell Derived Chemotaxin 1 |
| TGFB1 | 0.142750411 | Angiogenesis via Notch signaling pathway [55] |