Table 4.
Chronic (>12m) CRPS patient serum (n=20) pronociceptive effects in muMT fracture mice
| CRPS Patient ID | CRPS Duration (months) | Sex | Age | CRPS Cause | Allodynia | Edema | NRS | 3 wk post FX mice | FX mice 7d post serum injection | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allodynia (Δg) | Unweighting (%) | Allodynia (Δg) | (% Δ) | Unweighting (%) | (% Δ) | ||||||||
| KN | 14 | F | 29 | Leg Injury | Yes | Yes | 9 | −0.9 | 18 | −0.8 | −19 | 15 | −14 |
| Gi-1 | 15 | F | 53 | Hand SX | Yes | Yes | 4 | −0.8 | 20 | −1.0 | 29 | 17 | −14 |
| WK-9 | 16 | M | 31 | Hand Injury | No | Yes | 6 | −1.0 | 14 | −0.6 | −33 | 13 | −7 |
| WK-8 | 22 | F | 33 | Hand Injury | No | Yes | 6 | −0.9 | 19 | −0.2 | −77 | 13 | −28 |
| WK-7 | 24 | F | 46 | Ankle Injury | Yes | Yes | 7 | −1.0 | 19 | −1.4 | 48 | 14 | −26 |
| Gi-13 | 27 | F | 57 | Wrist FX | Yes | Yes | 4 | −0.9 | 16 | −0.8 | −18 | 15 | −7 |
| WK-1 | 38 | F | 55 | Hand FX | Yes | Yes | 7 | −0.7 | 14 | −0.6 | −12 | 13 | −13 |
| Gi-6 | 41 | F | 45 | Wrist FX | No | Yes | 9 | −0.9 | 14 | −0.8 | −2 | 16 | 14 |
| JR | 41 | F | 55 | Ankle SX | Yes | No | 8 | −1.1 | 18 | −0.8 | −28 | 13 | −27 |
| PO1.SO | 47 | F | 52 | Knee SX | Yes | Yes | 8 | −1.0 | 16 | −0.9 | −12 | 14 | −13 |
| JC | 49 | F | 57 | Toe FX | No | Yes | 9 | −0.9 | 15 | −0.9 | 11 | 14 | −12 |
| SL | 67 | F | 40 | Ankle SX | No | Yes | 9 | −1.0 | 18 | −0.8 | −19 | 14 | −21 |
| NR | 72 | F | 41 | Ankle Injury | No | Yes | 6 | −0.9 | 14 | −0.9 | 9 | 10 | −29 |
| DH | 75 | F | 49 | Foot FX | Yes | Yes | 7 | −0.9 | 17 | −0.7 | −25 | 15 | −11 |
| LMC | 76 | F | 42 | Foot Injury | Yes | Yes | 7 | −1.0 | 16 | −1.2 | 18 | 16 | −3 |
| BW | 83 | F | 30 | Foot Injury | No | No | 7 | −0.9 | 16 | −0.9 | −7 | 14 | −14 |
| Gi-10 | 84 | F | 52 | Ankle FX | Yes | No | 8 | −0.9 | 17 | −0.9 | 6 | 16 | −4 |
| LJ | 89 | F | 28 | Arm Injury | No | Yes | 9 | −1.1 | 20 | −1.2 | 11 | 17 | −15 |
| VP | 125 | F | 30 | Wrist FX | Yes | Yes | 7 | −1.0 | 19 | −0.7 | −28 | 16 | −12 |
| TB | 162 | F | 52 | Ankle FX | No | Yes | 9 | −0.9 | 15 | −0.7 | −20 | 15 | 0 |
The mean duration of CRPS was 58.4 ± 8.7 months at the time of serum collection, the average age was 44.6 ± 2.3 years, and the majority of patients were female (95%). The average pain numerical rating score (NRS) was 7.2 ± 0.4. Allodynia was present in 55% of patients, limb edema was present in 85% of patients, and 40% had suffered a fracture (FX). All FX mice had allodynia and unweighting in the injured hindlimb at 3 weeks post FX. The average change in FX mouse hindpaw allodynia at 7 days (7d) after patient serum intraperitoneal injection was −8 ± 6% and the change in hindlimb unweighting was −13 ± 3%. Post injection changes in allodynia or unweighting that reached the 25% increase significance criteria are listed in Bold font. FX: fracture, SX: surgery, CTS: carpal tunnel syndrome, wk: week, (Δg): difference between contralateral hindpaw threshold and fracture hindpaw threshold, thus a negative value represents increased allodynia, (% Δ): % change between 3 wk post FX value and 7d post serum injection value, thus a positive value represents an increase in allodynia or unweighting.