Table 6.

Orthopedic trauma without CRPS patient serum (n=15) had no effects in muMT fracture mice

Patient ID	Time Since Injury (months)	Sex	Age	Type of Injury	Allodynia	Edema	NRS	3 wk post FX mice		FX mice 7d post serum injection
								Allodynia (Δg)	Unweighting (%)	Allodynia (Δg)	(%Δ)	Unweighting (%)	(%Δ)
PD-1	2	M	57	Foot FX/SX	No	Yes	2	−0.9	14	−0.9	8	15	9
PD-2	1.5	F	58	Foot SX	No	No	1	−0.8	14	−0.7	−9	15	10
PD-3	1.5	M	71	Foot SX	No	No	0	−0.9	15	−0.7	−17	14	−8
PD-4	1	M	73	Foot SX	No	No	0	−0.9	14	−0.6	−36	14	0
PD-5	2	M	51	Ankle FX/SX	No	No	0	−0.9	17	−0.7	−13	14	−15
PD-6	2	M	47	Foot FX/SX	Yes	No	1	−0.8	15	−0.8	−1	14	−6
PD-7	9	M	51	Ankle SX	Yes	Yes	2	−0.8	15	−0.7	−19	13	−12
PD-8	1.5	M	72	Ankle SX	No	No	0	−0.8	15	−0.6	−21	15	−1
PD-9	2.5	M	75	Leg FX/SX	No	Yes	0	−0.8	14	−0.9	8	4	0
PD-10	1.5	M	56	Foot SX	Yes	No	0	−0.8	14	−0.7	−19	−15	5
PD-11	2.5	F	59	Foot SX	Yes	No	0	−0.9	15	−0.8	−7	−14	2
PD-12	1.5	M	46	Foot FX/SX	Yes	Yes	2	−0.9	16	−0.7	−23	−14	−9
PD-13	1	F	53	Foot FX/SX	Yes	Yes	0	−0.8	15	−0.5	−38	−17	−7
PD-14	5	F	56	Foot FX/SX	No	No	0	−0.8	16	−0.8	−6	−13	−17
PD-15	4	M	67	Ankle FX/SX	No	Yes	1	−0.8	15	−0.4	−54	−13	−13

The mean time since injury was 2.6 ± 0.5 months at the time of serum collection, the average age was 59.5 ± 2.5 years, and the majority of patients were male (73%). The average pain numerical rating score (NRS) was 0.6 ± 0.2. Allodynia was not present in any of the patients, limb edema was present in 40% of patients, and 53% had suffered a fracture. All FX mice had allodynia and unweighting in the injured hindlimb at 3 weeks post FX. Post injection changes in allodynia or unweighting that reached the 25% increase significance criteria are listed in Bold font. FX: fracture, SX: surgery, (Δg): difference between contralateral hindpaw threshold and fracture hindpaw threshold, thus a negative value represents increased allodynia, (% Δ): % change between 3 wk post FX value and 7d post serum injection value, thus a positive value represents an increase in allodynia or unweighting after serum injection.