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Plasma HO-1 levels rise after SnPP injection in participants with stage 3 CKD (15–29 ml/min per 1.73 m2) and stage 4 CKD (30–59 ml/min per 1.73 m2). Plasma HO-1 levels were measured at baseline and from 1 to 4 days after 27- or 90-mg SnPP injection. Time- and dose-dependent HO-1 increases were noted in both CKD stage 3 (CKD3) and CKD stage 4 (CKD4) groups. P<0.001, all in-group comparisons; ANOVA, repeated measures. The mean values/95% confidence intervals are depicted.
