Table 2.
Associations of continuous eGFR with individual gait variables
| Gait Variable | eGFR≥60, per 10-ml/min per 1.73 m2 Lower eGFR, n=196 | eGFR<60, per 10-ml/min per 1.73 m2 Lower eGFR, n=134 | Age, per 5-yr Older Age, n=330 | |||
|---|---|---|---|---|---|---|
| Coefficient (95% CI) | P Value | Coefficient (95% CI) | P Value | Coefficient (95% CI) | P Value | |
| Walking while talking | ||||||
| Speed, cm/s | 0.01 (−2.7 to 2.7) | 0.99 | −3.3 (−6.1 to −0.4) | 0.03 | −6.1 (−8.2 to −4.0) | <0.001 |
| Cadence, steps per 1 min | −0.7 (−3.0 to 1.7) | 0.57 | −1.0 (−3.5 to 1.5) | 0.43 | −1.7 (−3.5 to 0.2) | 0.07 |
| Step length, cm | 0.6 (−0.6 to 1.7) | 0.35 | −1.8 (−3.0 to −0.6) | 0.005 | −3.5 (−4.4 to −2.6) | <0.001 |
| Swing, % | 0.5 (0.01 to 1.1) | 0.05 | −1.1 (−1.7 to −0.6) | <0.001 | −0.9 (−1.3 to −0.5) | <0.001 |
| Stance, % | −0.5 (−1.1 to −0.01) | 0.05 | 1.1 (0.6 to 1.7) | <0.001 | 0.9 (0.5 to 1.3) | <0.001 |
| Double support, % | −0.4 (−1.2 to 0.5) | 0.38 | 1.4 (0.5 to 2.3) | 0.003 | 1.8 (1.2 to 2.5) | <0.001 |
| Step time SD, s | 0.02 (−0.01 to 0.05) | 0.20 | −0.01 (−0.04 to 0.03) | 0.77 | 0.01 (−0.01 to 0.03) | 0.39 |
| Swing time SD, s | 0.01 (−0.01 to 0.02) | 0.36 | −0.01 (−0.02 to 0.01) | 0.50 | 0.01 (−0.00 to 0.02) | 0.29 |
| DTC | ||||||
| Speed DTC, % | 0.4 (−2.0 to 2.7) | 0.76 | −1.3 (−3.8 to 1.2) | 0.30 | −1.2 (−3.0 to 0.6) | 0.18 |
| Cadence DTC, % | −0.2 (−2.3 to 1.9) | 0.87 | −0.9 (−3.1 to 1.3) | 0.41 | −0.5 (−2.1 to 1.1) | 0.53 |
| Step length DTC, % | 0.5 (−0.9 to 1.9) | 0.46 | −0.6 (−2.0 to 0.9) | 0.42 | −1.3 (−2.3 to −0.2) | 0.02 |
| Swing DTC, % | 1.3 (0.03 to 2.6) | 0.04 | −1.8 (−3.2 to −0.5) | 0.01 | −0.9 (−1.9 to 0.1) | 0.09 |
| Stance DTC, % | −0.6 (−1.2 to 0.01) | 0.05 | 0.9 (0.2 to 1.5) | 0.01 | 0.3 (−0.2 to 0.7) | 0.29 |
| Double-support DTC, % | −0.9 (−2.5 to 0.7) | 0.26 | 1.5 (−0.2 to 3.2) | 0.09 | 1.1 (−0.2 to 2.3) | 0.10 |
| Step time SD DTC, % (n=327) | 144.4 (−69.8 to 358.6) | 0.19 | −62.0 (−288.5 to 164.4) | 0.59 | 17.9 (−145.9 to 181.7) | 0.83 |
| Swing time SD DTC, % (n=329) | 58.2 (−16.0 to 132.5) | 0.12 | −34.3 (−113.2 to 44.6) | 0.39 | −7.9 (−65.0 to 49.2) | 0.79 |
Multivariable linear regression adjusting for age, sex, race, education, body mass index, neuropathy, number of comorbidities, and number of medications was performed. Linear splines for eGFR were constructed with knot placed at 60 ml/min per 1.73 m2. DTC = (walking while talking dual-task gait variable – walking-only single-task gait variable)/(walking-only single-task gait variable) ×100%. 95% CI, 95% confidence interval; DTC, dual-task cost.