Figure 5.
Photomicrographs of mice renal tissues. Rats were treated as Figure 2. Renal tissues of control mice showed normal renal tubules and glomeruli (A) (H&E ×40). Renal tissues of biologically synthesized CuO-NPs exposed mice showed glomerular hypercellularity (short arrow); severe coagulative necrosis, detached tubular epithelia and loss of brush border (long arrow); intraluminal hyaline casts (black star) in cortex (B1) (H&E ×40) and medulla (black star) (B2) (H&E ×10). (C1, C2) Chemically synthesized CuO-NPs exposed mice showed intertubular hemorrhage (star); cloudy swelling with, narrowing of tubular lumens (long arrow); glomerular hypercellularity (short arrow) (C1); pyknotic nuclei and tubular cell necrosis (long arrow) and intertubular hemorrhage (star) (C2) (H&E ×40).