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. 2020 Apr 15;31(6):1226–1242. doi: 10.1681/ASN.2019090923

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Copyright © 2020 by the American Society of Nephrology

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Figure 9. — Double deletion of Kir4.1 and Nedd4-2 impairs NCC function. (A) A scatter plot showing the Δ values of HCTZ-induced net E_Na in WT (Nedd4l^flox/flox/Kcnj10^flox/flox), Ks-Nedd4-2/Kir4.1 KO, and Ks-Kir4.1 KO mice. (B) A scatter line graph showing the results of each experiment in which the effect of single-dose HCTZ (30 mg/kg body wt [BW]) on urinary Na⁺ excretion (E_Na) within 120 minutes was measured with the renal clearance method in WT (Nedd4l^flox/flox/Kcnj10^flox/flox) and Ks-Nedd4-2/Kir4.1 KO mice. The significance is determined by t test. (C) A scatter line graph showing the results of each experiment in which the effect of single-dose HCTZ (30 mg/kg BW) on urinary K⁺ excretion (E_K) within 120 minutes was measured with the renal clearance method in WT (Nedd4l^flox/flox/Kcnj10^flox/flox) and Ks-Nedd4-2/Kir4.1 KO mice. (D) A scatter plot shows the plasma K⁺ concentrations in WT (Nedd4l^flox/flox and Nedd4l^flox/flox/Kcnj10^flox/flox), Ks-Nedd4-2 KO, Ks-Nedd4-2/Kir4.1 KO, and Ks-Kir4.1 KO mice. The experiments were performed in the mice treated with doxycycline followed by a 14-day recovery period.