Figure 2.

Nephron Pkd1 KO reduces blood pressue when fed a high salt diet. (A) Systolic and (B) diastolic arterial pressure and (C) heart rate in control and Pkd1 KO mice were determined on a normal Na⁺ diet for 4 days, a low Na⁺ diet for 4 days, and a high Na⁺ diet for 8 days; n=11 each data point. (D) shows GFR in Pkd1 KO and control mice after 2 days on a normal diet and a high salt diet (n=6 each data point). *P=0.05 KO versus control on the same day.