Figure 3.

Nephron Pkd1 KO increases urine volume and Na⁺ and K⁺ excretion during high salt administration. Illustrated are (A) food and (B) water intake, (C) urine volume, (D) urine K⁺ excretion, and (E) urine Na⁺ excretion; n=16 each data point. *P=0.05 KO versus control on the same day. (F) shows the effect of an acute 1.5-ml intraperitoneal saline injection on cumulative urinary Na⁺ excretion over the ensuing 7 hours (given to mice during normal salt intake); n=11 each data point. *P=0.05 KO versus control at the same time point.