Table 1.
The potential microbial peptide mimicking the critical amino acids of α3127–148
| Peptide | Sequencea | Adjusted Sequenceb | Protein | Species |
|---|---|---|---|---|
| B1 | AGFGWIDLWYGVLFGV | 4-Hydroxybenzoate polyprenyltransferase | Inquilinus limosus | |
| B2 | TWIQLWHGTPFKKMLF | Hypothetical protein | Staphylococcus sp. EGD-HP3 | |
| B3 | ARWISLWLFFMFINQP | ARWISLWLFFMFKK | O-antigen flippase Wzx | Bacillus sp. JCM 19046 |
| B4 | TFPDWIPLWGGESFVF | WIPLWGGESFVFKK | Peptidase A8 | Prevotella multiformis |
| B5 | YMKIQLWICLWFLFDF | QLWICLWFLFDFKK | Potassium channel protein | Bacteroides |
| B6 | YFLFQWILLWKNRSFK | Amino acid racemase | Clostridium sp. CL-2 | |
| B7 | GRWIVLWVEFQFTHAS | GRWIVLWVEFQFKK | UDP-N-acetylenolpyruvoylglucosamine reductase | Actinomyces sp. S4-C9/A. europaeus |
| B8 | WISLWKKAEFLQGLSP | Hypothetical protein | Bacillus sp. J37 | |
| B9 | GLWIGLWSGTTFTFNP | WIGLWSGTTFTFKK | gp240 | Mycobacterium phage ScottMcG |
| B10 | KQFLWIVLSLWTGFTF | WIVLSLWTGFTFKK | Cytochrome C oxidase | Comamonas testosteroni |
| B11 | HFLWVLIALWTGFTFI | WVLIALWTGFTFKK | Cytochrome C oxidase | Ralstonia pickettii |
| B12 | HSAWILIALWTGFTFV | WILIALWTGFTFKK | Cytochrome C oxidase | Ralstonia sp. UNC404CL21Col |
| B13 | MELNIWIALWAGFVSF | IWIALWAGFVSFKK | Cytochrome C biogenesis protein | Paenibacillus |
| B14 | KHFLWIVIALWTGFTF | WIVIALWTGFTFKK | Cytochrome C oxidase | Cupriavidus sp. Amp6 |
| B15 | AVVLWILLWLGAGVSG | WILLWLGAGVSGKK | Envelope glycoprotein C | Human herpesvirus 1 |
| B16 | GRGWITLWKCFKCAGP | Hypothetical protein | Paenibacillus alvei | |
| B17 | DMDGNWIGLWKGKDKW | Hypothetical protein | Proteobacteria bacterium | |
| B18 | LERRWIDLWGKLGFKE | Hypothetical protein | Prevotella sp. MA2016 | |
| B19 | PWIWLWAPNFYFPLSG | Hypothetical protein ×994_4209 | Burkholderia sp. TSV202 | |
| B20 | PFWVWILLWIFLFANF | WILLWIFLFANFKK | Hypothetical protein | Alloscardovia omnicolens |
| B21 | AWIWLWGFEWALLALA | AWIWLWGFEWALKK | Membrane protein | Streptomyces sp. NRRL B-1347 |
| B22 | TEEGWILLWEPKYFDD | Hypothetical protein | Streptococcus sobrinus | |
| B23 | IVIGWIFLWAFVDKLF | WIFLWAFVDKLFKK | Membrane protein | Actinotalea ferrariae CF5–4 |
| B24 | LGQWISLWVYGFSLVL | GQWISLWVYGFSKK | Multispecies: hypothetical protein | Acinetobacter |
| B25 | KVVIWIALWTPLFAFL | Conjugal transfer protein TraG | Acinetobacter baumannii | |
| B26 | YDTWIDLWESGKFPDI | CRISPR-associated protein CasA | Streptococcus oralis | |
| B27 | LAFLNWIRLWKSFKTE | Putative membrane protein | Leptospira sp. B5–022 | |
| B28 | CLTGWIGLWPMAGFLI | TGWIGLWPMAGFKK | Putative uncharacterized protein | Akkermansia sp. CAG:344 |
| B29 | FISNWITLWKGDLIGT | Hypothetical protein FEM08_33490 | Flavobacterium sp. EM1308 | |
| B30 | EVNLWIALWAGVASFI | LWIALWAGVASFKK | Cytochrome C biogenesis protein | Paenibacillus sp. UNC451MF |
| B31 | PDWISLWGFFQSEMKYF | Glycosyl transferase | Proteobacteria bacterium | |
| B32 | NPIQWIKLWSEMELFLF | LysR family transcriptional regulator | Bacillus subtilis | |
| B33 | CLWIGLWGNFPFALGP | Xanthine permease | Oscillospiraceae bacterium | |
| B34 | QWIYLWLKGFESGELR | Hypothetical protein | Clostridiales bacterium | |
| B35 | RGWIMLWGVGFFAVGL | GWIMLWGVGFFAKK | Hypothetical protein | Acinetobacter soli |
| B36 | TGAWIHLWGKGANGGS | gp34 | Mycobacterium phage |
CRISPR, clustered regularly interspaced short palindromic repeats.
a
The key amino acids are underlined.
b
Peptides were too hydrophobic to be synthesized and their sequences were adjusted to increase hydrophilicity.