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Differential regulation of AQPs in Pax mutants. Immunostaining for AQPs 1–4 as indicated (red) and LTL (green) in adult kidneys from mice with the indicated Pax gene deletions. Expression of AQP1 protein appears unaffected in all mutants, whereas Pax2/8 double KOs exhibit decreased expression of AQPs 2–4 in the inner and outer medulla. Representative sections are shown from immunostainings done with three independent kidneys for each genotype.
