Table 4.
uCD163 in patients with repeated biopsies on follow-up
| Patient | First Biopsy (diagnostic biopsy at flare) | Follow-up | Second Biopsy (per protocol or per-cause) | Outcomes | ||||
|---|---|---|---|---|---|---|---|---|
| Histopathology | uCD163 (ng/mmol) | 12-mo Response | uCD163 (ng/mmol) | Indication | Histopathology | uCD163 (ng/mmol) | Last Follow-up (mo) | |
| 11 | Class IV+V | 2807 | Complete response | 3 mo: 595 | Relapse at 28th mo | Class IV+V | 7964 | No response to reinduction (36 mo) |
| AI=12 | 6 mo: 248 | AI=6 | ||||||
| CI=3 | 12 mo: 87 | CI=7 | ||||||
| 12 | Class III+V | 950 | Complete response | 3 mo: 1032 | Relapse at 27th mo | Class V | 802 | Complete response to reinduction (35 mo) |
| AI=2 | 6 mo: 0 | AI=0 | ||||||
| CI=4 | 12 mo: 0 | CI=3 | ||||||
| 45 | Class IV+V | 1075 | Partial response | 3 mo: 2397 | Protocol at 12th mo | Class III | 368 | Complete response (20 mo) |
| AI=8 | 6 mo: 457 | AI=1 | ||||||
| CI=3 | 12 mo: 368 | CI=2 | ||||||
| 46 | Class IV+V | 22,072 | Partial response | 3 mo: 330 | Protocol at 12th mo | Class III | 211 | Partial response (20 mo) |
| AI=11 | 6 mo: 169 | AI=1 | ||||||
| CI=3 | 12 mo: 211 | CI=3 | ||||||
| 49 | Class IV+V | 3581 | Partial response | 3 mo: 428 | Protocol at 12th mo | Class III+V | 562 | Renal relapse (19 mo) |
| AI=10 | 6 mo: 308 | AI=4 | ||||||
| CI=5 | 12 mo: 562 | CI=3 | ||||||
| 50 | Class IV+V | 5401 | Complete response | 3 mo: 428 | Protocol at 12th mo | Class IV | 182 | Complete response (18 mo) |
| AI=14 | 6 mo: 232 | AI=1 | ||||||
| CI=2 | 12 mo: 182 | CI=4 | ||||||
| 52 | Class IV+V | 10,889 | Complete response | 3 mo: 125 | Protocol at 12th mo | Class III | 92 | Complete response (18 mo) |
| AI=16 | 6 mo: 114 | AI=1 | ||||||
| CI=4 | 12 mo: 92 | CI=4 | ||||||
| 99 | Class III+V | 3492 | Complete response | 3 mo: 50 | Protocol at 12th mo | Class III | 24 | Complete response (15 mo) |
| AI=3 | 6 mo: 87 | AI=0 | ||||||
| CI=3 | 12 mo: 24 | CI=4 | ||||||
| 118 | Class III+V | 2082 | Partial response | 3 mo: 238 | Protocol at 12th mo | Class III | 356 | Partial response (12 mo) |
| AI=10 | 6 mo: 137 | AI= 1 | ||||||
| CI=3 | 12 mo: 356 | CI= 2 | ||||||
| 119 | Class III+V | 7338 | Complete response | 3 mo: 352 | Protocol at 12th mo | Class III | 95 | Complete response (12 mo) |
| AI=4 | 6 mo: 0 | AI= 1 | ||||||
| CI=4 | 12 mo: 95 | CI = 7 | ||||||
| 120 | Class IV+V | 9169 | Partial response | 3 mo: 2138 | Protocol at 12th mo | Class III | 207 | Partial response (12mo) |
| AI=4 | 6 mo: 0 | AI= 1 | ||||||
| CI=4 | 12 mo: 207 | CI= 3 | ||||||
| 14 | Class IV+V | 1048 | No response | 3 mo: 7189 | No response at 12th mo | Class IV+V | 1500 | No response (32 mo) |
| AI=12 | 6 mo: 5738 | AI=12 | ||||||
| CI=6 | 12 mo: 1500 | CI=6 | ||||||
| 16 | Class III | 4267 | No response | 3 mo: 5098 | No response at 12th mo | Class IV+V | 14,796 | Progression to ESKD (16 mo) |
| AI=7 | 6 mo: 8318 | AI=17 | ||||||
| CI=1 | 12 mo: 14,796 | CI=5 | ||||||
| 35 | Class IV | 1675 | No response | 3 mo: 1220 | No response at 12th mo | Class IV+V | 1412 | DSCr (21 mo) |
| AI=3 | 6 mo: 1676 | AI=6 | ||||||
| CI=6 | 12 mo: 1412 | CI=7 | ||||||
| 37 | Class IV+V | 36,803 | No response | 3 mo: 20,578 | No response at third mo | Class IV+V | 20,578 | Progression to ESKD (3 mo) |
| AI=12 | AI=13 | |||||||
| CI=6 | CI=10 | |||||||
| 56 | Class IV+V | 18,922 | No response | 3 mo: 14,690 | No response at 24th mo | Class IV | 2336 | Response to change of IS (31 mo) |
| AI=11 | 6 mo: 8281 | AI=4 | ||||||
| CI=4 | 12 mo: 1998 | CI=7 | ||||||
| 65 | Class IV+V | 991 | No response | 3 mo: 10,462 | No response at sixth mo | Class IV+V | 2789 | Response to change of IS (14 mo) |
| AI=8 | 6 mo: 2789 | AI=10 | ||||||
| CI=6 | CI=5 | |||||||
| 105 | Class IV+V | 4718 | No response | 3 mo: 2526 | No response at sixth mo | Class IV+V | 1121 | Progression to ESKD (10 mo) |
| AI=5 | 6 mo: 1121 | AI=12 | ||||||
| CI=3 | CI=5 | |||||||
| 117 | Class IV+V | 1600 | No response | 3 mo: 3646 | No response at sixth mo | Class IV | 2390 | DSCr (12 mo) |
| AI=9 | 6 mo: 2390 | AI=8 | ||||||
| CI=7 | CI=10 | |||||||
AI, activity index; CI, chronicity index; IS, immunosuppression.