Table 1 |.
Serum and urine analyses for renal function of 12- to 15-month-old mice
Wild type (n = 13) | Ctns−/− (n = 16) | Gal-3−/− (n = 5) | Ctns−/− Gal-3−/− (n = 34) | |
---|---|---|---|---|
Serum | ||||
Creatinine (mg/dl) | 0.29 ± 0.02 | 0.41 ± 0.03a | 0.26 ± 0.02b | 0.31 ± 0.01b |
Urea (mg/dl) | 48.95 ± 3.25 | 90.35 ± 3.34a | 52.68 ± 2.15b | 77.43 ± 2.49a,b,c |
Phosphate (mg/dl) | 13.84 ± 1.07 | 12.87 ± 1.03 | 12.06 ± 0.28 | 12.03 ± 0.46 |
Urine | ||||
Phosphate (µmol/24 h) | 4.30 ± 0.62 | 5.56 ± 0.75 | 2.89 ± 0.81 | 6.06 T 0.81 |
Protein (mg/24 h) | 12.36 ± 1.96 | 13.06 ± 2.04 | 14.69 ± 3.94 | 12.51 ± 1.42 |
Volume (ml) | 0.85 ± 0.14 | 1.29 ± 0.14 | 0.89 ± 0.25 | 1.25 ± 0.12 |
Gal-3, Galectin-3.
P value was calculated by 1-way analysis of variance followed by Tukey’s test.
P < 0.05 compared with wild-type mice.
P < 0.05 compared with Ctns−/− mice.
P < 0.05 compared with Gal-3−/− mice.