FIG 2.

DEGs in the liver play a role in inflammation and metabolism. (A) Functional enrichment of DEGs within cluster 1 generated using MetaCore. The bar graph indicates the –log₁₀ FDR corrected P value. Numbers next to the bars indicate the number of DEGs that mapped to each GO term. (B) Network image showing DEGs that directly interact with one another from cluster 1 that mapped to the GO term “metabolic process” generated using MetaCore. (C) Heatmap of DEGs within cluster 1 that mapped to the GO terms “response to wounding,” “response to hormone,” and “inflammatory response.” Each column represents the median normalized transcript counts (RPKM) for each gene at each time point as follows: N (naive; n = 4), d2 (2 DPI; n = 4), d4 (4 DPI; n = 2), d6 (6 DPI; n = 4). The range of colors is based on scaled and centered RPKM values of the entire set of genes, with red indicating highly expressed and blue indicating lowly expressed genes. (D) Functional enrichment of DEGs within cluster 2 generated using MetaCore. (E) Heatmap of DEGs in cluster 2 that enriched to “response to stress” and “immune response.” Each column represents the median normalized transcript counts (RPKM) for each gene at each time point: N (naive; n = 4), d2 (2 DPI; n = 4), d4 (4 DPI; n = 2), d6 (6 DPI; n = 4). The range of colors is based on scaled and centered RPKM values of the entire set of genes, with red indicating highly expressed genes and blue indicating lowly expressed genes.