Immunofluorescence staining in the placenta for macrophages (red) (blue, DAPI). (A) In both FP isolate-infected dams, only an occasional macrophage was observed in the maternal and fetal compartments of the placenta (arrow). (B and C) In the PR isolate-infected dams that were ZIKV IF and RNA positive, macrophages were more abundant, particularly in the maternal compartment of the placenta (C, arrow). Arrowheads denote autofluorescing red blood cells.