TABLE 3.
Homologous genesa shared between four known virophages and large/giant viruses
| Virophage ORF (no. of amino acids) | Homology with protozoan giant virus (NCBI protein accession no.) (alignment length/identity/E value) | Homology with large/giant algae virus-Accession no. (Alignment length/Identity/E value) |
|---|---|---|
| Sputnik | ||
| ORF06 (310) | Mamavirus collagen triple helix repeat protein-( AEQ60378.1) (251/76%/9e-107) | Paramecium bursaria Chlorella virus CviKI hypothetical protein ( AGE51678.1) (140/28%/3e-6) |
| ORF12 (152) | Mamavirus hypothetical protein ( AEQ60743.1) (122/70%/8e-58) | — |
| ORF13 (779) | Mimivirus DNA replication (AVG46848.1) (454/58%/0) | Heterosigma akashiwo virus 01 D5-ATPase-helicase ( AOM63458.1) (354/25%/1e-11) |
| ORF14 (114) | Moumouvirus Monve hypothetical protein tv_L8 (AEY99266.1) (58/60%/1e-17) | — |
| ORF16 (130) | Moumouvirus hypothetical protein (AQN67875.1) (83/49%/1e-16) | — |
| ORF17 (88) | Moumouvirus australiensis transcriptional regulator ( AVL93333.1) (51/43%/1e-7) | — |
| Mavirus | ||
| ORF20 (152) | Cafeteria roenbergensis virus BV-PW1 hypothetical protein crov514 ( YP_003970147.1) (112/49%/2e-25) | — |
| Zamilon | ||
| ORF08 (81) | Moumouvirus Monve hypothetical protein tv_L8-( AEY99266.1) (53/72%/3e-21) | — |
| ORF09 (778) | Mimivirus DNA replication ( AVG46848.1) (456/73%/0) | Heterosigma akashiwo virus 01 D5-ATPase-helicase ( AOM63458.1) (340/24%/4e-14) |
| ORF15 (305) | Mimivirus collagen triple helix repeat-containing protein (AKI78955.1) (192/72%/5e-82) | — |
| ORF19 (147) | Mimivirus low complexity ( AVG46387.1) (129/50%/3e-37) | — |
| RNV | ||
| ORF03 (245) | Pithovirus hypothetical protein ( QBK89714.1) (226/27%/1e-18) | — |
| ORF04 (139) | Moumouvirus zinc finger C2H2-type domain-containing protein ( AEY99263.1) (73/37%/8e-12) | — |
| ORF06 (310) | Mamavirus collagen triple helix repeat containing protein (AEQ60378.1) (251/76%/1e-107) | — |
| ORF08 (184) | Pithovirus hypothetical protein ( QBK89712.1) (112/32%/1e-7) | — |
| ORF12 (152) | Mamavirus hypothetical protein (AEQ60743.1) (122/70%/5e-59) | — |
| ORF13 (779) | Mimivirus DNA replication (AVG46848.1) (454/58%/0) | — |
| ORF14 (114) | Moumouviru hypothetical protein (AEY99266.1) (58/60%/3e-18) | — |
| ORF16 (130) | Moumouvirus hypothetical protein AQN67875.1) (83/49%/4e-17) | — |
| ORF20 (442) | Marseillevirus nucleotidyl transferase ( QBK88130.1) (354/28%/8e-36) | — |
a
E value, <10−5; coverage, >40%. Nonredundant homologous genes are shown in boldface. –, Not determined.