FIG 11.

Model for the role of DRB2 in virus infection. In a well-established host-virus interaction, the robust antiviral RNAi response can efficiently limit virus amplification and prevent the buildup of significant amounts of viral dsRNA (left panel). During a mixed virus infection, due to the hampered antiviral RNAi response, virus infection gets out of control, resulting in the accumulation of virus-derived dsRNAs. The excess viral dsRNA interacts with DRB2, triggering necrotic responses (right panel). See further details in the text. RF, replicative form RNA.