TABLE 3.
MIC and FICI results with the combinations of MIN and azoles against E. dermatitidis
| Strain | MICa (μg/ml) for: |
||||||
|---|---|---|---|---|---|---|---|
| Agent alone |
Combinationb |
||||||
| MIN | ITC | VRC | POS | MIN/ITC | MIN/VRC | MIN/POS | |
| BMU00028 | >64 | 1 | 2 | 1 | 4/1(I) | 8/0.5(S) | 4/0.25(S) |
| BMU00029 | >64 | 1 | 0.5 | 1 | 16/1(I) | 16/0.25(I) | 16/0.25(S) |
| BMU00030 | >64 | 2 | 0.5 | 1 | 16/0.5(S) | 8/0.25(I) | 8/0.5(I) |
| BMU00034 | >64 | 2 | 0.5 | 0.5 | 8/0.5(S) | 8/0.125(S) | 4/0.25(I) |
| BMU00035 | >64 | 1 | 1 | 1 | 16/0.5(I) | 16/0.5(I) | 8/0.25(S) |
| BMU00036 | >64 | 1 | 1 | 0.5 | 8/0.25(S) | 8/0.5(I) | 16/0.125(S) |
| BMU00037 | >64 | 2 | 0.5 | 1 | 16/0.5(S) | 16/0.25(I) | 8/1(I) |
| BMU00038 | >64 | 1 | 0.5 | 1 | 8/1(I) | 8/0.125(S) | 8/0.25(S) |
| BMU00039 | >64 | 1 | 0.5 | 1 | 4/0.25(S) | 16/0.125(S) | 8/0.25(S) |
| BMU00040 | >64 | 1 | 0.5 | 0.5 | 8/0.25(S) | 8/0.5(I) | 8/0.5(I) |
| 109140 | >64 | 2 | 0.5 | 0.5 | 8/0.5(S) | 8/0.125(S) | 4/0.25(I) |
| 109144 | >64 | 1 | 1 | 1 | 4/0.25(S) | 8/0.25(S) | 8/0.125(S) |
| 109145 | >64 | 1 | 0.5 | 1 | 4/0.25(S) | 4/0.125(S) | 8/0.25(S) |
| 109148 | >64 | 1 | 0.5 | 0.5 | 4/0.25(S) | 8/0.25(I) | 4/0.25(I) |
| 109149 | >64 | 1 | 0.5 | 1 | 8/0.5(I) | 8/0.25(I) | 8/0.25(S) |
| 109152 | >64 | 1 | 0.5 | 1 | 4/0.25(S) | 4/0.125(S) | 4/0.125(S) |
a
The MIC is the concentration achieving 100% growth inhibition.
b
FICI results are shown in parentheses. S, synergy (FICI of ≤ 0.5); I, no interaction (indifference) (0.5 < FICI ≤ 4).