TABLE 2.
Covariate hypothesis testing in the model developmenta
| Model description | OFV | ΔOFV | P value |
|---|---|---|---|
| Basic model | 1,009.90 | ||
| Full covariate model (V-WT Cl-PTA Cl-CLcr) | 976.127 | ||
| Backward elimination | |||
| Removing Cl-PTA Cl-CLcr | 980.868 | 4.741 | <0.05 |
| Removing Cl-CLcr | 1,005.726 | 24.858 | <0.01 |
| Removing CL-PTA | 992.308 | 11.44 | <0.01 |
a
OFV, objective function value; V, the volume of distribution; CL, clearance; WT, body weight; PTA, prothrombin activity; CLcr, creatinine clearance rate; ΔOFV, change in the OFV compared to reference model.