TABLE 4.

Percentage of patients with distribution probability of AUC_0–24/MIC and C_min,ss in each simulated population^a

Dosage (mg/12 h)	PTA (%)	CLcr (ml/min)	% of patients by Cmin,ss (μg/ml) category			% of patients by distribution probability of AUC0–24/MIC
						MIC of 2 μg/ml			MIC of 4 μg/ml
			<2	2–8	>8	<80	80–100	>100	<80	80–100	>100
600	80	99.3b	3.7	95.4	0.9	6.0	12.0	82.0	64.3	19.7	16.0
	40	99.3b	0.3	74.2	25.5	0	0.3	99.7	7.1	12.8	80.1
	20	99.3b	0	35.6	64.4	0	0	100	0	0.3	99.7
	80	50	0.6	94.6	4.8	1.8	2.9	95.3	23.2	38.9	37.9
	80	30	0.2	89.2	10.6	0.3	2	97.7	19.4	21.7	58.9
	80	10	0	65.9	34.1	0	0	100	3.1	5.0	91.9
300	80	99.3b	37.3	62.7	0	64.3	19.7	16.0	98.8	0.9	0.3
	40	99.3b	2.6	97.3	0.1	7.1	12.8	80.1	66.9	17.9	15.2
	20	99.3b	0	99.8	0.2	0	0.3	99.7	8.1	14.8	77.1
	80	50	13.6	86.4	0	37.9	23.2	38.9	93.8	4.4	1.8
	80	30	5.2	94.8	0	19.2	21.8	59.0	84.3	9.6	6.1
	80	10	0.5	99.4	0.1	3.1	4.7	92.2	29.1	23.8	47.1
200	80	99.3b	84.1	15.9	0	91.3	6.6	2.1	100	0	0
	40	99.3b	32.6	67.4	0	34.5	21.9	43.6	93.3	4.2	2.5
	20	99.3b	3.4	96.6	0	2.1	3.3	94.6	40.1	19.1	40.8
	80	50	67.2	32.8	0	77.3	13.7	9.0	99.6	0.4	0
	80	30	52.9	42.1	0	56.7	21.0	22.3	98.2	0.6	1.2
	80	10	20.1	79.9	0	10.7	25.0	64.3	84.1	9.3	6.6

^an = 1,000. PTA, prothrombin activity; CLcr, creatinine clearance rate; C_min,ss, minimum steady-state concentration.

^bMedian value.