FIG 6.

Comparison of the IMP-13 meropenem-bound structure with previously published metallo-β-lactamase structures. IMP-13 is always depicted with an orange loop, and the IMP-13-bound meropenem is depicted in salmon. (A and C) Two views of IMP-13 overlaid with IMP-1 bound to the mercaptocarboxylate inhibitor (yellow; PDB accession number 1DD6 [60]). (B and D) Overlay of IMP-13 with NDM-1 and hydrolyzed meropenem (green; PDB accession number 5N0H [67]). The phenylalanine residue at the tip of the loop is not resolved in the structure, but the backbone is shown as sticks. (E) Overlay of IMP-13 with IMP-1 bound to the bisthiazoline inhibitor L-VC26 (cyan; PDB accession number 5EWA [57]). (F) Overlay of IMP-13 with IMP-1 bound to a phosphonate-based inhibitor (purple; PDB accession number 5HH4 [61]).