FIG 3.

Exposure-response relationship for cefepime-enmetazobactam against Klebsiella pneumoniae. Pharmacodynamics of cefepime-enmetazobactam in a murine lung model with Klebsiella pneumoniae 1280740 as the challenge strain. Data are the means and standard deviations from n = 3 mice. The solid blue squares are the pretreatment and end-of-therapy vehicle-treated controls, with expansion of approximately 1-log over a 24-h period. The solid red line is the fit of an inhibitory sigmoid E_max model to the data. The broken blue line is the stasis line (i.e., the pretreatment control obtained 2 h postinoculation). Half-maximal activity is achieved with a regimen of 100 mg/kg cefepime q8h plus 4.71 mg/kg enmetazobactam q8h.