FIG 5.

Threshold plasma concentration of enmetazobactam where regrowth is observed. The modeled enmetazobactam plasma concentration that allows regrowth is 0.07 mg/liter. The 2.5-mg/kg enmetazobactam regimen (solid red line) administered on a q4h schedule results in killing for approximately 47% of the dosing interval. The solid black circle indicates regrowth at 1.89 h postdose for the 2.5-mg/kg q4h schedule. The 7.5-mg/kg enmetazobactam regimen (solid blue line) administered on a q12h schedule results in killing for approximately 32% of the dosing interval. The solid black triangle indicates regrowth at 3.84 h postdose for the 7.5-mg/kg q12h schedule.