TABLE 2.

Parameter estimates from the population PK models fit to total drug concentration-time profiles for cefepime and enmetazobactam^a

Parameterb	Cefepime			Enmetazobactam
	Mean	Median	SD	Mean	Median	SD
SCL (liters/h)	0.043	0.043	0.005	0.040	0.040	0.007
V (liters)	0.007	0.007	0.000	0.009	0.010	0.003
kcp (h−1)	4.046	3.654	1.510	0.868	0.639	0.499
kpc (h−1)	28.185	29.607	3.205	0.731	0.559	0.370
kcd (h−1)	0.350	0.325	0.082
kdc (h−1)	0.837	0.797	0.278

^aThe mean and median parameter estimates, and their standard deviations, obtained from the population PK models fit to cefepime and enmetazobactam total drug concentration-time profiles. The point estimates of the population median parameter values for both cefepime and enmetazobactam were used for the PK modeling and estimation of drug exposure.

^bSCL is the first-order clearance of enmetazobactam from the central compartment; V is the volume of the central compartment; k_cp, k_pc, k_cd, and k_dc are the first-order intercompartmental rate constants.