TABLE 2.
Resistance genes and amino acid changes as determined by whole-genome sequencing analyzed with the ResFinder database and CLC Main Workbench 8.1a
| Gene product | Strain |
|||
|---|---|---|---|---|
| ARU617 | ARU620 | ARU622 | ARU623 | |
| β-Lactamases | blaOXA-50 (T16A, Q25R) blaPAO (-) blaTEM-1C (-) | blaOXA-50 (T16A, Q25R) blaPAO (P7S, G27D, T105A, V205L, V356I, G391A) | blaOXA-50 (R49C, D109E, R167H) blaPAO (-) | blaOXA-10 (-) blaOXA-50 (R49C, D109E, R167H) blaPAO (R79Q, T105A) |
| Aminoglycoside-modifying enzymes | aph(3′)-IIb (A107V, E243A) | aph(3′)-IIb (A21V, P184L, D188N) | aac(6′)-Ib (-) aph(3′)-IIb (S14A) aph(6)-Id (-) | aac(6′)-Ib (-) aadA3 (-) aph(3′)-IIb (S14A) aph(6)-Id (-) |
| Glutathione transferase | fosA (-) | fosA (-) | fosA (-) | fosA (-) |
| Chloramphenicol O-acetyltransferase | catB7 (-) | catB7 (V97A, G100D, M176I, T195A) | catB7 (-) | catB7 (-) |
a
P. aeruginosa PAO1 was used as a reference (NCBI reference sequence NC_002516). -, no amino acid change detected.