TABLE 1.
Top hits in primary antiviral screen
| DTP NSC no.a | Primary screen hit value | Antiviral name | Description | Prior antiviral activity against:b |
|---|---|---|---|---|
| 407286 | 16.97 | Lagistase | Naturally occurring plant phenol; antioxidant and metabolism-modulating properties | HIV (34), HRV (35), HBV (36) |
| 11905 | 5.76 | Lapachol | Naphthoquinone from the lapacho tree; anti-inflammatory and antiproliferation agent | EBV (37), EV (38) |
| 41833 | 3.97 | Superacyl | Base analog | |
| 122023 | 3.19 | Valinomycin | Potassium ionophore | HRV (39), SARS-CoV (28), RSV (40), PV (41) |
| 51787 | 3.19 | 5-Isoquinolinol | Metal chelating agent | |
| 24819 | 2.93 | β-peltatin | Glycoside from Podophyllum roots | MV, HSV (42) |
| 401005 | 2.84 | Pleurotine | Antifungal agent; thioredoxin inhibitor | |
| 44175 | 2.59 | Polyporin | Benzoquinone isolated from Hapalopilus nidulans; dihydroorotate dehydrogenase inhibitor | |
| 712807 | 2.48 | Capecitabine | Antimetabolite antineoplastic agent | |
| 15307 | 2.45 | Quininone | Quinine metabolite | |
| 36398 | 2.20 | Taxifolin | Polyphenol from milk thistle seeds | HAV (43), HIV (44) |
| 38010 | 2.15 | Chaulmoogric acid ethyl ester | Ethyl ester of long-chain fatty acid from chaulmoogra seeds | |
| 747972 | 2.10 | Lenalidomide | Antiangiogenic factor, used to treat multiple myeloma | |
| 718781 | 2.04 | Tarceva | Epidermal growth factor receptor inhibitor antineoplastic agent, used to treat pancreatic and non-small cell lung cancer | |
| 301683 | 2.02 | Daphnetin | Antioxidant agent; coumarin; used in traditional Chinese medicine to treat cardiovascular disease | |
| 755985 | 1.88 | Nelarabine | Antimetabolite antineoplastic agent, used to treat T-cell acute lymphoblastic leukemia | |
| 5366 | 1.81 | Noscapine | Antitussive agent | |
| 279836 | 1.76 | Mitoxantrone | Topoisomerase inhibitor; antineoplastic agent | HIV (45), VACV (46), HCV (47), HSV (48), RVFV (16) |
| 11440 | 1.64 | Protopine | Calcium channel blocker and anti-inflammatory agent | |
| 11926 | 1.60 | Tardolyt | Carcinogenic molecule from birthwort plants | HSV (49) |
a
NSC, National Service Center.
b
HIV, human immunodeficiency virus; HRV, human rhinovirus; HBV, hepatitis B virus; EBV, Epstein-Barr virus; EV, enterovirus; SARS-CoV, severe acute respiratory syndrome coronavirus; RSV, respiratory syncytial virus; PV, poliovirus; MV, measles virus; HSV, herpes simplex virus; HAV, hepatitis A virus; VACV, vaccinia virus.