FIG 5.
Microbiological outcome in study 2. (A and B) Response to treatment for 1 week. (C and D) Response to treatment for 2 weeks. Panels A and C show results for monotherapy, and panels B and D show combination treatment groups. Solid lines indicate fall in mean CFU (±standard error of the mean [SEM]) during treatment, and dashed lines show reduction after stopping treatment. After 1 week of treatment, Q203-containing regimens showed a marked dose response, and although CFU counts at week 1 were not significantly different than RC controls, more dramatic reductions occurred during the 4-week follow-up period after stopping treatment. All Q203-containing regimens except Q0.5 were significantly better after 1 week of treatment than RC treatment for 2 weeks. After 2 weeks of treatment, all Q203-containing regimens were significantly better than RC control after 2 weeks and rendered footpads negative at follow-up 2 weeks after stopping treatment.